Prothrombin G20210A and FLV mutations were found to be the most frequent causes of inherited thrombophilia in the Caucasian populations. We observed that 20% of our cohorts had FVL mutation compared to the typical figures of 3-7% reported in the general populations; this relatively higher incidence of our results might be attributed to the small sample size that amplified the prevalence of this mutation and the fact that patients with MPDs in the current study were more likely to undergo genetic testing for thrombophilia, leading to a higher detection rate. The gene discussed is F5; the disease is Rare hereditary thrombophilia.