INS and type 1 diabetes mellitus: New Zealand rabbits, 20 weeks old and all female, were divided into three groups, each consisting of nine individuals, totaling twenty-seven. DM was induced through intraperitoneal alloxan injection at a dosage of 115 mg/kg before implant placement. The type of DM induced was T1DM, necessitating insulin medication. The onset of diabetes occurred on the second day post-induction, marking the commencement of the study