INS and type 1 diabetes mellitus: Wistar rats, specifically male, were utilized with six rats per group, totaling 48 rats. Diabetes was induced in the rats through the administration of 80 mg/kg Streptozocin prior to implant placement. The type of diabetes modeled was T1DM, managed with insulin. Notably, a slow-release insulin-coated implant was used during the implant placement process, ensuring sustained medication delivery