INS and diabetes mellitus: 30 male Sprague–Dawley rats, aged 11 weeks, were divided into five groups of 6 rats, and used to investigate the effects of T1DM on implant outcomes. Diabetes was induced using a 30 mg/kg dose of Streptozocin to create a model of T1DM, and insulin was administered as the treatment medication. The induction of diabetes occurred before the implant placement, ensuring the condition was established prior to the intervention