In order to enhance glycolysis, cancer cells need to control intra-cellular PH levels by carrying lactate into the extracellular space via two major lactate transporters, monocarboxylate transporter 1 (MCT1) and monocarboxylate transporter 4 (MCT4), both strongly expressed in PDAC (Kong et al., 2016). Here, SLC16A1 is linked to cancer.