NGF and neoplasm: NGF released by tumor cells promotes neuritic growth (D'Haese et al., 2013; Dai et al., 2007; Bapat et al., 2016; Ceyhan et al., 2008b), reduces apoptosis and increases proliferation of cancer cells leading to PDAC aggressiveness (Bapat et al., 2016; Bapat et al., 2011a; Miknyoczki et al., 1999; Miknyoczki et al., 2002; Zhu et al., 2002).