This study investigates the correlation between the expression levels of ten genes associated with SUMOylation (HDAC1, HDAC4, HDAC9, PIAS1, PIAS2, RAN, RANBP2, SUMO1, RANGAP1, SUMO1) and overall survival (OS) across various cancer types, as illustrated in Figure 1. This evidence concerns the gene PIAS1 and cancer.