This study investigates the correlation between the expression levels of ten genes associated with SUMOylation (HDAC1, HDAC4, HDAC9, PIAS1, PIAS2, RAN, RANBP2, SUMO1, RANGAP1, SUMO1) and overall survival (OS) across various cancer types, as illustrated in Figure 1. The gene discussed is HDAC1; the disease is cancer.