It is synthesized by sphingomyelin synthase 1 and 2 (SGMS1/2) isoenzymes, with SGMS1 being the primary isoform present at significantly lower levels in cancer cell membranes, including GBM, and reduced expression of SGMS1 in gliomas is associated with poorer prognostic outcomes (Fernández-García et al., 2019; Lladó et al., 2014). Here, SGMS1 is linked to glioblastoma.