SMPD1 and central nervous system cancer: Recent preclinical research indicates that antidepressant fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI), can inhibit SMPD1 and induce cell death in glioma by accumulating sphingomyelin, which results in inhibition of oncogenic EGFR signaling and activating lysosomal stress (Bi et al., 2021).