Hsp27 belongs to chaperones exhibiting eminent neuroprotective activity in various neurological pathologies (Akbar et al., 2003; Shimura et al., 2004; Abisambra et al., 2010) including brain hypoxia and stroke (Stetler et al., 2008; Badin et al., 2006, 2009; Liu et al., 2010b; Tucker et al., 2011; Teramoto et al., 2013; Yu et al., 2013; Leak et al., 2013; Zhan et al., 2017; Shimada et al., 2018; Behdarvandy et al., 2020). This evidence concerns the gene HSPB1 and Stroke.