ACSL4 and ischemic stroke: For example, Hsp90 has been shown to facilitate the pathways of cellular death caused by oxidative damage (Selim and Ratan, 2004) and to activate Acyl-CoA synthetase long-chain family member 4 (ACSL4)—the factor permitting ferroptosis—driven by accumulation of lipid hydroperoxides in ischemic stroke (Miao et al., 2022).