EZH2 and small cell lung carcinoma: Enhancer of zeste homolog (EZH2), an enzymatic subunit of Polycomb Repressive Complex 2, could catalyze trimethylation of H3K27 to silence genes, whereas the inhibition of EZH2 induced MHC-I expression and immune responses in preclinical models of advanced NE tumors, including SCLC (46, 84, 85).