RB1 and small cell lung carcinoma: RB1 inactivation is obligatory in SCLC (5) and loss of RB1 not only can cause tissue cancerous but also can lead to impaired immune response and significant attenuation of genes related to immune function, suggesting the relationship between RB1 and immune characteristics (57), whereas wild-type (WT) RB1 was a surrogate marker for yes-associated protein 1 (YAP1) expression in SCLC and related to the survival and chemotherapy responsiveness of patients (58).