KEGG analysis showed that up-regulated genes were enriched in immune-related signaling pathways, including cytokine-cytokine receptor interaction, leukocyte transendothelial migration, chemokine signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, as well as extracellular matrix and adhesion related pathways, such as ECM-receptor interaction, focal adhesion, and cell adhesion molecules (CAMs) (Figure 9B). Here, CD274 is linked to cancer.