As excepted, compound probiotics treatment significantly alleviated colonic disease in CEBS mice, increased colon length [Figures 4B, C, 95% CI, (0.6149, 0.8180); P < 0.01], and decreased fecal water content in CEBS + Mix mice [Figure 4D, 95% CI, (−6.223, −1.632]; P < 0.05]. This evidence concerns the gene MIXL1 and colonic disorder.