PVs in ATP1A2, which encodes for a catalytic subunit of sodium/potassium ATPase, are responsible for FHM Type 2 (FHM2, OMIM: 602481).6 The clinical spectrum ranges from migraine without aura to migraine with typical aura and pure hemiplegic phenotype, variably associated with epilepsy and/or intellectual disability.7-9. This evidence concerns the gene ATP1A2 and Intellectual disability.