In the same aminoacidic position, another PV [ATP1A2: c.1843G > A, p.(Gly615Arg)] was previously identified.11,12 In synthesis, the c.1844G > A was classified as LPV (Class IV) since fulfilling the PM2, PM5, PP1, and PP3 criteria, according to the American College of Medical Genetics classification.13 The same PV was present in all subjects screened displaying signs compatible with the diagnosis of migraine with and without aura and HM (9/14). This evidence concerns the gene ATP1A2 and migraine disorder.