Our observation of a concomitant effect of the CSF p-tau/Aβ42 ratio on both fibrillary Aβ deposition and on GMV in regions sensitive to the Alzheimer’s disease pathology in asymptomatic individuals suggests that this hybrid marker may be sensitive in predicting the clinical trajectory, as already observed in samples at more advanced stages.22-25. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.