(Ishisaka et al., 2011) reported that in some behavioral tests, such as forced swimming test (FST) and tail suspension test (TST), chronic oral administration of luteolin exhibited an anti‐depressant‐like effect by decreasing the expression of stress‐related proteins in the hippocampus endoplasmic reticulum of mice with depression treated with CORT. This evidence concerns the gene CORT and depressive symptom measurement.