Similarly, inhibition in tumor growth of athymic nude mice bearing LNCaP cell xenografts has been observed by betulinic acid treatment and this result was associated with reduction in the expression of Sp1, Sp3, and Sp4 proteins and vascular endothelial growth factor (VEGF) and increased apoptosis in tumors (Chintharlapalli et al. 2007). The gene discussed is VEGFA; the disease is neoplasm.