HK2 and hereditary clear cell renal cell carcinoma: Moreover, it was reported that the mammalian target of rapamycin (mTOR) activation is important for the betulin‐induced cytotoxicity in renal cell carcinoma, as mTOR increased pyruvate kinase muscle isozyme M2PKM2 and hexokinase 2 (HK2) expression by upregulating the aerobic glycolysis (Cheng et al. 2017).