Considering the influence of mitochondrial biogenesis during cardiac hypertrophy and the profound impact of SIRT1/PGC‐1α signaling on mitochondrial biogenesis and metabolism, Mei et al. (2020) showed that isosteviol (a terpenoid derived from stevioside) exerted a cardioprotective effect in isoprenaline/high glucose (ISO‐/HG)‐induced myocardial hypertrophy. Here, PPARGC1A is linked to cardiac hypertrophy.