In our literature review, we found that natural compounds in pathological conditions such as cardiomyopathy (Li, Feng, et al. 2021), I/R (Yu et al. 2019), and cardiac hypertrophy (Hou et al. 2021) could induce NRF‐1 and NRF‐2 which activate antioxidant‐responsive element (ARE). Here, NRF1 is linked to cardiac hypertrophy.