Its anticancer effects in CRC can be emerged by stimulation of the bone morphogenetic protein 7(BMP7)/p38 mitogen‐activated protein kinases (p38MAPK)/p53 or p38MAPK/phosphatase & 10 sin homolog (PTEN) signaling pathways (Liu et al. 2018; Wu et al. 2016). This evidence concerns the gene TP53 and colorectal carcinoma.