In this context, in a study examining the function of TP in the progression of inflammatory bowel disease, TP was found to induce classically activated macrophages (M1) to alternatively activated macrophages (M2) repolarization of RAW 264.7 macrophages via mTOR/signal transducer and activator of transcription 3 (STAT3) signaling. This evidence concerns the gene STAT3 and inflammatory bowel disease.