AKT1 and malignant colon neoplasm: Finally, the apigenin glycoside isovitexin decreased the expression levels of p‐PI3K, p‐Akt, p‐mTOR, and Bcl‐2 and significantly increased the levels of Bax and caspase‐3 in human colon cancer epithelial cells (Zhu, Zhao, and Jiang 2021).