Quercetin shows its therapeutic effect on CRC by modulating signal cascades, involving PI3K/Akt/mTOR, Wnt/β‐catenin, MAPK/ JNK, MAPK/Erk, MAPK/p38, NF‐κB and p‐53 (Arts et al. 2004; Atashpour et al. 2015; Bruning 2013; Howells et al. 2019; Russo et al. 2012; Shi, Tian, and Tian 2021; Zhai et al. 2022). This evidence concerns the gene TP53 and colorectal carcinoma.