DMC‐BH inhibited the proliferation and invasion and promoted the apoptosis of HCT116 and HT 29 cells. The Akt pathway activator SC79 reversed the proapoptotic effects of DMC‐BH on CRC cells, indicating that its effects are mediated by PI3K/AKT/mTOR signaling. Here, AKT1 is linked to colorectal carcinoma.