Further dietary flavonoids and polyphenolic compounds have applications in diabetes due to effects on lipid peroxidation, glucose absorption by GLUT2, and the inhibition of insulin dependent PI3K, activation of AMPK (Stewart et al. 2009; Alam, Meerza, and Naseem 2014) and decreased the genetic expression of PPARγ (Stanley Mainzen Prince and Kamalakkannan 2006). The gene discussed is INS; the disease is diabetes mellitus.