There is a functional link between the COPII machinery involved in anterograde trafficking, that is known to be impaired in TANGO2 disease, and autophagy, as COPII vesicles serve as a membrane precursor for autophagosome biogenesis.50–55 TRAPPopathies due to TRAPPC11 or TRAPPC12 mutations, that present neurological features associated with possible rhabdomyolysis, display a defect in both trafficking machinery between the ER and the Golgi apparatus and autophagy 56–58, similarly to TANGO2. Here, TRAPPC11 is linked to rhabdomyolysis.