In addition, top-ranking signaling pathways mainly included arginine and proline metabolism, IL-17 signaling pathway, AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, serotonergic synapse, histidine metabolism, lipid and atherosclerosis, metabolic pathways, tryptophan metabolism, VEGF signaling pathway and leishmaniasis. The gene discussed is IL17A; the disease is atherosclerosis.