In addition, top-ranking signaling pathways mainly included arginine and proline metabolism, IL-17 signaling pathway, AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, serotonergic synapse, histidine metabolism, lipid and atherosclerosis, metabolic pathways, tryptophan metabolism, VEGF signaling pathway and leishmaniasis. Here, AGER is linked to atherosclerosis.