On the other hand, an extreme systemic immune response (“cytokine storm”), direct attack of pancreatic β-cells by SARS-CoV-2 by binding to ACE2, and an unbalanced immune response can, in turn, lead to glycemic profile disorders, uncontrolled hyperglycemia, and progression of IR in persons with T2D (15, 16). This evidence concerns the gene ACE2 and type 2 diabetes mellitus.