REN and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: The 2015 Kidney Disease: Improving Global Outcomes (KDIGO) guideline systematically addresses autosomal dominant tubulointerstitial nephropathy (2); five ADTKD-causing genes (MUC1, UMOD, REN, HNF1B, and SEC61A1) and their corresponding genotypes have been identified (3).