IDH1 and central nervous system cancer: These findings pair well with the hypothesis that patients with IDH1-wild tumors, which are generally more aggressive and grow faster, present with more severe deficits due to greater lesion momentum, which may impede compensatory neuroplasticity and cerebral reorganization in the short-term; on the other hand, the lack of circuitry rewiring might result in better long-term recovery after tumor removal, as discussed above for HGG/LGG gliomas (41, 44, 73).