Derks and colleagues showed in a cohort of 54 diffuse glioma patients how patients with isocitrate dehydrogenase-mutated (IDH-mut) glioma have a better prognosis but suffer more often of epilepsy with respect to patients with IDH-wild type glioma, who are generally older and more often have neuropsychological deficits (75). This evidence concerns the gene IDH3A and glioma.