The risk of developing AD is 2–3 times higher with one ε4 allele and about 12 times higher in those with two ε4 alleles compared to ApoE ε3.108 People with ApoE ε4 polymorphism suffer from impaired glucose metabolism, increased oxidative stress, and enhanced neuroinflammation as potential molecular drivers of AD as reviewed previously.109 In contrast, ApoE ε2 is protective against development of AD.110 Beside genetic predisposition, various comorbidities contribute to AD development. The gene discussed is APOE; the disease is Alzheimer disease.