This ideais supported by transcriptomic dynamics during TCF4 loss offunction, as well as by studies of DNA-protein interactionsusing ChIP-Seq technology, indicating that common pathogeneticpathways seem to be involved in the pathogenesis ofPTHS and some psychiatric disorders (Xia et al., 2018; Phanet al., 2020). Here, TCF4 is linked to psychiatric disorder.