TCF4 and Pitt-Hopkins syndrome: Amiel J., Rio M., De Pontual L., Redon R., Malan V., Boddaert N.,Plouin P., Carter N.P., Lyonnet S., Munnich A., Colleaux L. Mutationsin TCF4, encoding a class I basic helix-loop-helix transcriptionfactor, are responsible for Pitt-Hopkins syndrome, a severe epilepticencephalopathy associated with autonomic dysfunction.