In this study, we characterized six-month-old B6.Cg-Tg(PrNp-SNCA*A53T)23Mkle/J mice for markers importantfor Parkinson’s disease manifestation, such as motor coordinationand body balance, as well as the density of dopamineneurons and alpha-synuclein neurons in the substantia nigra.Six-month-old B6.Cg-Tg mice show early signs of Parkinson’sdisease. Here, PRNP is linked to Parkinson disease.