Another key feature of PD is the accumulation of alphasynucleinin brain neurons, particularly in the SNC and STR(Dickson et al., 2009; Burre et al., 2018; Lai et al., 2021).Alpha-synuclein regulates synaptic activity, including dopaminesynthesis, transport, and storage (Burre et al., 2018;Bidesi et al., 2021). This evidence concerns the gene SNCA and Parkinson disease.