If partial deletions of AZFa andAZFb are extremely rare and are associated with reducedsperm production, then the role of partial deletions of AZFc(the most common are gr/gr, b2/b3, b1/b3) in spermatogenesisis controversial and the association with spermatogenesis variesgreatly (from normozoospermia to azoospermia), but theymay be compatible with natural conception or successfullyovercome by assisted reproductive technologies (Bansal et al.,2016a, b). The gene discussed is USP9Y; the disease is Azoospermia.