In the former, the clonal evolution of CLP is primarily driven by the overexpression of BCL2 due to IGH::BCL2, which prevents the translocation‐positive cells from apoptosis while undergoing germinal centre reactions, whereas in the latter, the clonal evolution of CLP is most likely driven by dysregulated immune responses (autoimmunity). The gene discussed is BCL2; the disease is Autoimmunity.