Level of 15‐oxo‐ETE in ISS was an independent variable, without any marked influence by age, sex, severity, asthma control, FEV1%, total IgE, blood eosinophils, dose of ICS, scores: ACT, mini‐AQLQ, SNOT‐22, and L‐M score and it was the best predictor to categorize patients into the NSAIDs‐ERD group. The gene discussed is IGHE; the disease is asthma.