In neurodegenerative diseases such as PD, AD, and ALS, aggregates of abnormal proteins, including α‐synuclein (α‐syn), β‐amyloid (Aβ), and TDP‐43, exhibit a markedly asymmetric distribution patterns in the brain [48, 49, 50, 51, 52, 53, 54]. The gene discussed is TARDBP; the disease is Alzheimer disease.