Although the precise molecular functions of DNA2 in astrocytes are unclear, and direct evidence linking it to glioma development is lacking, previous studies suggest a dual role for DNA2 in different cancer contexts: it acts as a tumor suppressor by maintaining genome integrity to prevent tumor transformation [47, 48], while also facilitating the survival of cancer cells during DSB repair and replication stress [49, 50]. This evidence concerns the gene DNA2 and glioma.