CD8A and neoplasm: Furthermore, we found that IM with EP generated significantly higher HPV16 E7-specific CD8 + T cell immune response compared to NFIS (Fig. 5B, C). We also showed that IM with EP tended to generate higher HPV16 E7-specific CD8 + T cell immune response compared to IM with needle alone, although significance was not reached (Fig. 5B, C). All treated mice had significantly slower tumor growth than that of untreated mice.