The downregulation of CAV1 and IDH3A and upregulation of ITGB4 in MRC5_coH196 cells compared to MRC5_Mo cells indicate that SCLC cells might regulate CAF glucose metabolism primarily through these genes, while the TGF-β signaling was not enriched in MRC5_coH196 cells. This evidence concerns the gene ITGB4 and small cell lung carcinoma.