After infusion with Ang II or saline for 28 days, no abnormal aortic morphology or spontaneous abdominal aortic aneurysm (AAA) was found in the saline-treated ApoE−/− Nox1y/fl and ApoE−/−Nox1SMCko mice (Fig. 1C). Here, APOE is linked to abdominal aortic aneurysm.