MAPT and supranuclear palsy, progressive, 1: Moreover, the PSP patients included scored at 20+ on the Mini-Mental State Examination (MMSE), which means that they already have moderate to severe cognitive and motor impairment, thus, much like the PD trials, it is possible that these treatments are also being administered at a stage where neurodegeneration and transcellular spread of tau have already caused irreversible damage.