In this work, RSL3 and STING agonist diABZi‐compound 3 (diABZi) were co‐loaded into hollow Bi2Se3 nanoparticles (HBN) to achieve concurrent amplification of tumor cell ferroptosis and systemic immune response, which were finally modified by pH‐responsive 1,2‐Distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐Poly(2‐ethyl‐2‐oxazoline) (DSPE‐Peoz) to obtain DP‐HBN/RA. The gene discussed is STING1; the disease is neoplasm.