On the other hand, senescent cells influence the surrounding microenvironment by secreting the SASP, which contains proinflammatory cytokines, growth factors, and enzymes that may facilitate tumor invasion and metastasis, as well as promote tumor angiogenesis, supplying the necessary nutrients and oxygen for tumor growth.[42, 43] Our research revealed that after B68 treatment, the levels of SASP‐related factors, such as IL6, GM‐CSF, CXCL3, and AREG, in colorectal cancer cells also significantly increased, indicating a certain degree of risk of immune suppression. This evidence concerns the gene AREG and colorectal cancer.