Consistent with our hypotheses, CSN5 was inversely correlated with pivotal elements of the cancer‐immunity cycle, including the release of tumor antigens, the priming and activation phase, the trafficking of immune cells to the tumor site, including the recruitment of CD4+ T cells, macrophages, dendritic cells, and NK cells, as well as the T cell‐mediated recognition of cancer cells in COAD and READ, with a pronounced negative correlation in COAD (Figure 9F,G). This evidence concerns the gene COPS5 and cancer.