B68 uniquely induces tumor cell senescence by directly targeting BMI1, which blocks the cell cycle and inhibits tumor growth, and also targets CSN5 to reduce the expression of PD‐L1, which blocks PD‐1/PD‐L1 immunosuppression, thereby enhancing the ability of the immune system to eliminate senescent tumor cells and exert antitumor effects, providing new research ideas and strategies for the treatment of colorectal cancer. The gene discussed is CD274; the disease is colorectal cancer.