Consequently, researchers have proposed a strategy that involves inducing senescence in tumor cells followed by the clearance of these senescent cells, which can effectively control the proliferation of premalignant cells and thus prevent the formation and progression of malignant tumors.[34, 35, 36, 37] Here, we found that B68, a derivative modified from berberine, can induce senescence in colorectal cancer cells by targeting BMI1, exerting an antitumor effect. This evidence concerns the gene BMI1 and neoplasm.