These results are consistent with the findings reported by Kim et al., who observed higher expression of SHH in lung adenocarcinoma patients with EGFR‐mutant, which was related to a poor prognosis.[57] Furthermore, the high expression rate of p‐STAT3 protein was significantly increased in EGFR‐mutant lung adenocarcinoma tissues. Here, SHH is linked to lung adenocarcinoma.