SHH is a crucial ligand of the Hh pathway, playing a pivotal role in cell differentiation, and proliferation.[38] In lung cancer tissues, the expression level of the SHH protein was significantly and positively correlated with p‐STAT3.[39] We then decided to further explore whether there is a specific regulatory relationship between them, thereby linking the Hh and STAT3 pathways. This evidence concerns the gene SHH and lung cancer.