To further explore the expression levels and correlation of SHH/DUSP13B/p‐STAT3 in lung adenocarcinoma tissues, we performed IHC staining and found that the high expression rate of SHH protein in EGFR‐mutant lung adenocarcinoma tissues was significantly higher than that in EGFR wild‐type tissues, which was consistent with the mRNA expression pattern. The gene discussed is SHH; the disease is lung adenocarcinoma.