EGFR gene mutations can lead to aberrant activation of a cascade of downstream pathways, such as JAK/STAT, PI3K/Akt, and MAPK, leading to tumor development.[56] We investigated the correlation between key molecules, including SHH, GLI1, DUSP13B, and STAT3, and the mutation status of EGFR using the TIMER2.0 online website. The gene discussed is GLI1; the disease is neoplasm.