Studies have demonstrated that itraconazole can inhibit the growth of liver cancer cells and promote apoptosis through the AKT/mTOR/S6K, reactive oxygen species (ROS), and Wnt/β‐catenin pathways, thereby exerting anticancer effects.[10] In esophageal cancer, itraconazole acts by inhibiting the HER2/AKT signaling pathway.[11] Although itraconazole exerts potent antitumor effects, its specific molecular mechanisms are not fully understood. Here, AKT1 is linked to liver cancer.