Moreover, the expression of fibronectin, collagen I and elastin were downregulated in the lung tissues of silicosis mice following interventions with 3PO and pioglitazone (Figure 4C), suggesting that the enhancement of FAO and inhibition of glycolysis can mitigate silica dust‐induced pulmonary fibrosis to differing extents. The gene discussed is FN1; the disease is silicosis.