HIF‐1α is not only a vital regulatory factor of glycolysis but also regulates other metabolic processes, such as fatty acid metabolism and amino acid metabolism.[15] However, it is unclear whether HIF‐1α promotes ECM deposition in silica‐induced pulmonary fibrosis by regulating the metabolic transition of FAO‐glycolysis. This evidence concerns the gene HIF1A and pulmonary fibrosis.