PPARG and silicosis: In our transcriptomic data, we observed an increase in HIF‐1α, a protein closely associated with metabolic regulation and which is implicated in several diseases.[16] Immunohistochemical staining of lung tissue from patients with IPF and silicosis revealed an upregulation of HIF‐1α in fibrotic lung tissue and a downregulation of (peroxisome proliferator‐activated receptor‐gamma) (PPAR‐γ) (Figure S5A, Supporting Information).