More importantly, the transcript expression of the key characteristic glycolytic genes was examined in the RNAseq data, which revealed that genes like Hif‐1α, phosphofructokinase‐1 (Pfk2), hexokinase 2 (Hk2), and lactate dehydrogenase A (Ldha) were upregulated in mouse lung tissues with silica‐induced fibrosis compared to control. This evidence concerns the gene HK2 and fibrosis.