EGR1, an important TF of HPSE, contributes to inflammation‐associated lung diseases.[53] It has been reported that EGR1 activation relies predominantly on the MAPK and cAMP signaling pathways[54] and is involved in apoptosis, autophagy, and fibrosis.[55, 56, 57] In addition, a derived engineered extracellular vesicle developed by Gu et al. The gene discussed is TF; the disease is lung disorder.