Reports have indicated that the Warburg effect is elevated and associated with immunological dysregulation and organ dysfunction during sepsis.[27, 28] Consistent with this observation, we found that the transcription and protein expression levels of HIF‐1α, HK3, PFKFB3, PKM2, and LDHA were increased in mouse lung tissue during S‐ALI (Figure 1D,E). This evidence concerns the gene PFKFB3 and Sepsis.