HK3 and Sepsis: Reports have indicated that the Warburg effect is elevated and associated with immunological dysregulation and organ dysfunction during sepsis.[27, 28] Consistent with this observation, we found that the transcription and protein expression levels of HIF‐1α, HK3, PFKFB3, PKM2, and LDHA were increased in mouse lung tissue during S‐ALI (Figure 1D,E).