Herein, using the stable cascade catalysis channel formed by polydopamine (PDA), imidazole groups, and Cu ions, a microgel system comprising functional monomers [superoxide dismutase (SOD) with double bonds, PDA, 2‐methacryloyloxy ethyl phosphorylcholine (MPC), and Cu ions] is proposed for managing PD. Here, SOD1 is linked to Parkinson disease.