Meanwhile, the dopamine (DA) released from PDA can facilitate DA storage and neurogenesis, inhibiting CX3CL1 release and the CX3CR1 receptor on microglia and further regulating the CX3CL1/CX3CR1‐NF‐κB‐NLRP3 signaling pathway in microglia to inhibit neuroinflammation. The gene discussed is NFKB1; the disease is Patent ductus arteriosus.