NUSAP1 and cancer: Suppression of NUSAP results in delayed entry into mitosis, defective cytokinesis, and short spindle.[2, 4] NUSAP deficiency in mice leads to early embryonic lethality, sustained spindle checkpoint activity, and mitotic arrest, eventually leading to caspase activation and apoptotic cell death.[5] NUSAP also plays a pivotal role in chromosome oscillation,[6] and it is upregulated in several types of cancer.[7]