DCs present cancer antigens to CD4 + T cells via MHC class II and to CD8 + T cells via MHC class I via costimulatory molecules and positive signals such as TCR, CD28, CD80/CD86, CD40, CD40L, OX40, OX40L, IL12, IFN-α, IFN-α and others [22–25]. The gene discussed is CD4; the disease is cancer.