Given that our results demonstrated a significant enhancement in RFS and OS rates in AML associated with elevated TRH expression levels (Figure 4A,B), we hypothesize that augmenting TRH expression within LSCs via the activation of the IFN‐α and IFN‐γ pathways is linked to increased chemosensitivity in AML, ultimately resulting in improved RFS and OS. Here, IFNG is linked to acute myeloid leukemia.