ATRX and neoplasm: Histopathology is paramount in the diagnosis of undifferentiated pleomorphic sarcoma; a combination of microscopy and immunohistochemical markers should be used for diagnosis.6 Undifferentiated pleomorphic sarcoma under microscopy demonstrates “atypical, pleomorphic spindle cells with abundant mitotic figures.”6 Tumor proteins such as Dickkopf-related protein 1, tumor protein p53, cyclin-dependent kinase inhibitor 2A, retinoblastoma-associated protein, and transcriptional regulator ATRX are all possible causes of tumorigenesis.6