CD8A and pulmonary tuberculosis: Furthermore, Similarly, in Mtb infection, key genes of Wnt/β-catenin signaling were impaired in blood cells of patients with severe pulmonary TB, furthermore, β-catenin expressions in CD8+T cells were significantly decreased in patients with severe pulmonary TB compared with those in mild diseases (Fan et al., 2017; Xiong et al., 2021).