Significant changes in Ki67 expression of Mtb-specific CD8+T cells were observed two months after the initiation of anti-TB chemotherapy, accompanied by decreased frequency of Mtb-specific CD8+T cells, and to the comparable levels as healthy controls at the end of treatment (Day et al., 2014; Li et al., 2020; Day et al., 2011; Nyendak et al., 2013). The gene discussed is CD8A; the disease is tuberculosis.