ART initiation in acute HIV infection promoted the persistence of HIV-specific CD8+TSCM cells, with high expansion and cytotoxic capacity, and mitigatory activated/exhausted phenotype, whereas ART initiation in chronic HIV infection led to more differentiated HIV-specific CD8+T cells with a higher combined frequency of short-lived T cells (Takata et al., 2022; Salido et al., 2018; Tartaro et al., 2022). This evidence concerns the gene CD8A and HIV infectious disease.