CD8A and HIV infectious disease: During acute HIV infection, memory CD8+T cells are driven toward a more terminally differentiated status, along with a decrease frequency of long-lived T cell subsets, including TSCM cells and TCM cells, promoting the differentiation of CD8+T cells with short-lived transitional memory (TTM cells) and effector memory (TEM cells) subsets (Takata et al., 2022).