It also turned out that KLF5 silencing enhanced the inhibitory effect of CD8+ T cells on HCC cell vitality, whereas M2‐exos and galectin‐3 overexpression reversed the above effect, and galectin‐3 overexpression further increased cell vitality in M2‐exos and sh‐KLF5 co‐treated HCC cells (Figure 6G). The gene discussed is CD8A; the disease is hepatocellular carcinoma.