To investigate the interaction between NEAT1, KLF5, and galectin‐3 in M2‐exo‐mediated effect on HCC immune escape, HCC cells were treated with M2‐exos combined with sh‐KLF5 and oe‐Gal‐3 co‐transfection. This evidence concerns the gene LGALS3 and hepatocellular carcinoma.