Among the 35 patients reviewed in the literature, except for Coombs-positive cases caused by AIHA, the autoantibodies in 11 patients were unknown, whereas anti-platelet antibodies, anti-neutrophil antibodies, anti-TPO antibodies, anti-IFN-α autoantibodies, and anti-nuclear antibodies were generated in other patients. This evidence concerns the gene TPO and autoimmune hemolytic anemia.