The distribution of top 30 genes, including seven gene candidates, in patient 4 between pre-invasive and invasive carcinomas was displayed, showing that three candidates from UBQLN2, NANOGNB and TAS2R46 genes were distributed in at least 2 out of 4 foci in the patient 4 (Figure 3C). This evidence concerns the gene UBQLN2 and invasive carcinoma.