In addition, we outline current potential therapeutic interventions, including interleukin (IL)-7, IL-15, IFN-γ, granulocyte-macrophage colony stimulating factor (GM-CSF), Fms-like tyrosine kinase-3 ligand, inhibition of programmed cell death protein 1(PD-1), programmed cell death ligand 1 (PD-L1), and other cell death checkpoints, as well as future directions for sepsis management. Here, CSF2 is linked to Sepsis.