In a mouse model of sepsis, IL-15 has been shown to attenuate sepsis-induced apoptosis of natural killer (NK) cells, dendritic cells, and CD8+ T cells by increasing the expression of the anti-apoptotic protein Bcl-2, and decreasing the expression of pro-apoptotic proteins Bim and PUMA (113). The gene discussed is BBC3; the disease is Sepsis.