DUBs such as CYLD and A20 control the inflammatory response by removing the K63 of the RIPK1 chain ubiquitin and inhibit the overactivation of downstream pro-inflammatory signaling to prevent uncontrolled inflammation, revealing that the dynamic balance between ubiquitination and deubiquitination is critical for the regulation of inflammation in sepsis (14). Here, RIPK1 is linked to Sepsis.