IL1B and Sepsis: However, in sepsis, dysregulation of ubiquitination (e.g., enhancement of the deubiquitinating enzyme BRCC3) increases the activity of NLRP3, which leads to the excessive activation of inflammatory vesicles, thereby exacerbating cellular pyroptosis and further releasing large amounts of pro-inflammatory cytokines (e.g., IL-1β and IL-18) (45).