Considering that histone modifications are associated with drug-induced CYP3A4 expression (110), further investigation of H3K4me3/H3K27me3 modifications at the CYP3A4 promoter region and PXR-mediated H4R3 acetylation influenced by the intestinal microbiota and its metabolites will provide valuable insights into the regulatory mechanisms of CYP3 expression in liver disease. This evidence concerns the gene CYP3A4 and liver disorder.